E 2 -mediated EMT by activation of β-catenin/Snail signalling during the development of ovarian endometriosis

Endometriosis is an oestrogen-dependent disease, and epithelial-mesenchymal transition (EMT) is involved in the process of endometriosis. Whether oestrogen could induce EMT in endometriosis remains largely unknown. Here, we reported that up-regulated expression of EMT markers in ovarian chocolate cy...

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Published in:Journal of cellular and molecular medicine 2019-12, Vol.23 (12), p.8035-8045
Main Authors: Xiong, Wenqian, Zhang, Ling, Liu, Hengwei, Li, Na, Du, Yu, He, Haitang, Zhang, Zhibing, Liu, Yi
Format: Article
Language:English
Subjects:
17-Hydroxysteroid Dehydrogenases - metabolism
Adult
beta Catenin - metabolism
Cadherins - metabolism
Catenin
Cell Movement - drug effects
Cells, Cultured
Chocolate
Chromatin Immunoprecipitation
Cysts
Endometriosis
Endometriosis - etiology
Endometriosis - metabolism
Endometrium
Endometrium - cytology
Endometrium - drug effects
Endometrium - metabolism
Epithelial cells
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Epithelial-Mesenchymal Transition - drug effects
Estradiol - pharmacology
Estradiol - physiology
Estrogens
Estrogens - pharmacology
Female
Gynecology
Humans
Infertility
Menstruation
Mesenchyme
Obstetrics
Ovarian cancer
Ovarian Cysts - metabolism
Pathogenesis
Receptors, Estrogen - antagonists & inhibitors
Reproductive health
RNA, Small Interfering
Signal Transduction - drug effects
Snail Family Transcription Factors - metabolism
Transcription
Transcription factors
Up-Regulation
Womens health
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container_issue 12
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creator Xiong, Wenqian
Zhang, Ling
Liu, Hengwei
Li, Na
Du, Yu
He, Haitang
Zhang, Zhibing
Liu, Yi
description Endometriosis is an oestrogen-dependent disease, and epithelial-mesenchymal transition (EMT) is involved in the process of endometriosis. Whether oestrogen could induce EMT in endometriosis remains largely unknown. Here, we reported that up-regulated expression of EMT markers in ovarian chocolate cyst is accompanied by high expression 17β-hydroxysteroid dehydrogenase 1 (17β-HSD1), and exposure of primary human endometrial epithelial cells to oestradiol conditions could promote EMT occurrence and activate both β-catenin and Snail signalling. Furthermore, we found nuclear β-catenin and Snail expression was closely linked in ovarian endometriosis, and β-catenin knockdown abrogated oestrogen-induced Snail mediated EMT in vitro. This is due to that β-catenin/ TCF-3 could bind to Snail promoter and activate its transcription. These results suggested that β-catenin signalling functions as the Snail activator and plays a critical role in oestradiol-induced EMT in endometriosis.
doi_str_mv 10.1111/jcmm.14668
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These results suggested that β-catenin signalling functions as the Snail activator and plays a critical role in oestradiol-induced EMT in endometriosis.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.14668</identifier><identifier>PMID: 31560827</identifier><language>eng</language><publisher>England: John Wiley &amp; Sons, Inc</publisher><subject>17-Hydroxysteroid Dehydrogenases - metabolism ; Adult ; beta Catenin - metabolism ; Cadherins - metabolism ; Catenin ; Cell Movement - drug effects ; Cells, Cultured ; Chocolate ; Chromatin Immunoprecipitation ; Cysts ; Endometriosis ; Endometriosis - etiology ; Endometriosis - metabolism ; Endometrium ; Endometrium - cytology ; Endometrium - drug effects ; Endometrium - metabolism ; Epithelial cells ; Epithelial Cells - drug effects ; Epithelial Cells - metabolism ; Epithelial-Mesenchymal Transition - drug effects ; Estradiol - pharmacology ; Estradiol - physiology ; Estrogens ; Estrogens - pharmacology ; Female ; Gynecology ; Humans ; Infertility ; Menstruation ; Mesenchyme ; Obstetrics ; Ovarian cancer ; Ovarian Cysts - metabolism ; Pathogenesis ; Receptors, Estrogen - antagonists &amp; inhibitors ; Reproductive health ; RNA, Small Interfering ; Signal Transduction - drug effects ; Snail Family Transcription Factors - metabolism ; Transcription ; Transcription factors ; Up-Regulation ; Womens health</subject><ispartof>Journal of cellular and molecular medicine, 2019-12, Vol.23 (12), p.8035-8045</ispartof><rights>2019 The Authors. 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subjects 17-Hydroxysteroid Dehydrogenases - metabolism
Adult
beta Catenin - metabolism
Cadherins - metabolism
Catenin
Cell Movement - drug effects
Cells, Cultured
Chocolate
Chromatin Immunoprecipitation
Cysts
Endometriosis
Endometriosis - etiology
Endometriosis - metabolism
Endometrium
Endometrium - cytology
Endometrium - drug effects
Endometrium - metabolism
Epithelial cells
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Epithelial-Mesenchymal Transition - drug effects
Estradiol - pharmacology
Estradiol - physiology
Estrogens
Estrogens - pharmacology
Female
Gynecology
Humans
Infertility
Menstruation
Mesenchyme
Obstetrics
Ovarian cancer
Ovarian Cysts - metabolism
Pathogenesis
Receptors, Estrogen - antagonists & inhibitors
Reproductive health
RNA, Small Interfering
Signal Transduction - drug effects
Snail Family Transcription Factors - metabolism
Transcription
Transcription factors
Up-Regulation
Womens health
title E 2 -mediated EMT by activation of β-catenin/Snail signalling during the development of ovarian endometriosis
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