Aluminium phosphide-induced testicular toxicity through oxidative stress in Wistar rats: Ameliorative role of hesperidin

The present study was designed to investigate aluminium phosphide (ALP)-induced testicular toxicity, including its effects on sperm parameters and histological alterations in Wistar rats, and the possible protective role of hesperidin (HSD). Oral administration of ALP at 1.15 mg/kg body weight (1/10...

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Bibliographic Details
Published in:Toxicology research and application 2018-01, Vol.2
Main Authors: Afolabi, Olusegun Kayode, Wusu, Adedoja Dorcas, Ugbaja, Regina, Fatoki, John Olabode
Format: Article
Language:English
Subjects:
Aluminum
Antioxidants
Body weight
Catalase
Chemical compounds
Damage
Glutathione peroxidase
Hesperidin
Lipid peroxidation
Lipids
Malondialdehyde
Morphology
Oral administration
Oxidative stress
Parameters
Peroxidase
Pharmacology
Phosphides
Reduction
Sperm
Superoxide dismutase
Testes
Toxicity
Viability
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Summary:The present study was designed to investigate aluminium phosphide (ALP)-induced testicular toxicity, including its effects on sperm parameters and histological alterations in Wistar rats, and the possible protective role of hesperidin (HSD). Oral administration of ALP at 1.15 mg/kg body weight (1/10 LD50) for 30 days resulted in a significant increase in testicular malondialdehyde, lipid hydroperoxides, and oxidized protein levels. These indicators of oxidative stress were accompanied by decreased activity of the antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase, followed by a drastic reduction in the non-enzymatic antioxidant indices of glutathione and total antioxidant capacity when compared to control. Furthermore, ALP treatment produced a marked reduction in sperm count, motility and viability while increasing abnormal sperm morphology and adverse histopathological changes in testis. Co-administration with HSD significantly ameliorated ALP-induced testicular damage by suppressing oxidative stress indices and enhancing antioxidant status while also improving the sperm parameters and histological alterations in ALP-treated rats. The results of the present study indicated that testicular toxic effects of ALP are due to oxidative imbalance and that HSD could be a potential therapeutic agent against ALP-induced testicular damage.
ISSN:2397-8473
2397-8473
DOI:10.1177/2397847318812794