Laxative utilization over time in chronic pain patients with opioid-induced constipation

To determine laxative utilization over time among chronic noncancer pain patients with opioid-induced constipation (OIC). A prospective longitudinal study conducted in the USA, Canada, Germany and UK. Patients on daily opioid therapy for treatment of chronic noncancer pain with OIC were recruited fr...

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Bibliographic Details
Published in:Pain management (London) 2016-11, Vol.6 (6), p.531-541
Main Authors: Datto, Catherine J, LoCasale, Robert J, Margolis, Mary Kay, Thompson, Christine L, Coyne, Karin S
Format: Article
Language:English
Subjects:
Analgesics
Chronic pain
Constipation
Data collection
Internet
Laxatives
Narcotics
opioid
pain
Pain management
Patients
Primary care
Probiotics
Quality of life
symptoms
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Summary:To determine laxative utilization over time among chronic noncancer pain patients with opioid-induced constipation (OIC). A prospective longitudinal study conducted in the USA, Canada, Germany and UK. Patients on daily opioid therapy for treatment of chronic noncancer pain with OIC were recruited from clinics to complete a survey at Baseline and weeks 2, 4, 6, 8, 12, 16, 20 and 24. 489 patients completed baseline with 452 completing one or more follow-up visits. 128 (28%) were nonlaxative users, 112 (25%) were insufficient laxative users and 212 (47%) were sufficient laxative users. The consistent sufficient laxative users reported the most bowel movements per week. The majority of OIC patients do not take or only intermittently take laxatives.
ISSN:1758-1869
1758-1877
DOI:10.2217/pmt-2016-0010