The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study

Objective: Bronchospasm is a very important complication that can be encountered during the post-operative and intraoperative periods. This complication may be caused by surgery, anesthesia, or patient-related issues. Many analgesics are preferred during the intraoperative period for post-operative...

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Bibliographic Details
Published in:Meandros medical and dental journal 2019-04, Vol.20 (1), p.82-86
Main Authors: Erdem, Ali Onur, Özkısacık, Sezen, Yazıcı, Mesut, Erel, Kamil Varlık
Format: Article
Language:English
Subjects:
Acetylcholine
Airway management
Analgesia
Analgesics
Anesthesia
Asthma
Atropine
Bronchospasm
Bronchus
Ibuprofen
Inflammation
Ketamine
Nonsteroidal anti-inflammatory drugs
Opioids
Ostomy
Pain perception
Paracetamol
Patients
Pediatrics
Smooth muscle
Surgery
Tıp
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Summary:Objective: Bronchospasm is a very important complication that can be encountered during the post-operative and intraoperative periods. This complication may be caused by surgery, anesthesia, or patient-related issues. Many analgesics are preferred during the intraoperative period for post-operative analgesia. In this study, we aimed to investigate the effects of ibuprofen and paracetamol on rat bronchus with supramaximal tonus as a model of bronchospasm under in vitro conditions. Materials and Methods: Totally, 20 male rats were used in our study. After the ketamine anesthesia, the left main bronchus of each rat was removed and suspended in the organ bath in Krebs solution. Four rat bronchi were excluded because of not demonstrating viability with atropine and acetylcholine. After demonstrating the viability of the rats’ bronchi (n=16), acetylcholine was applied to produce supramaximal contraction. The rats’ bronchi with supramaximal contraction were randomly divided into two groups. Paracetamol was applied to group 1, and ibuprofen to group 2. The contraction responses of each group were recorded and compared statistically. Results: While a statistical significance was not detected regarding the supramaximal contraction in group 1 with a mean of 0.18±0.07% (p>0.05), tonus was reduced to 6.79±0.28% (p
ISSN:2149-9063
2149-9063
DOI:10.4274/meandros.galenos.2018.72692