A Marker for Evaluation of Oxidative Stress in Patients with Alopecia Areta: Thiol-Disulphide Homeostasis

Objective: Alopecia areata (AA) is a disorder characterized by non-scarring hair loss, whose etiology involves oxidative stress. We aimed to determine the role of thiol/disulphide levels in AA pathogenesis and to investigate if they can be used as its marker. Materials and Methods: This prospective...

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Published in:Meandros medical and dental journal 2018-09, Vol.19 (3), p.205-210
Main Authors: Demir Pektaş, Suzan, Alataş, Emine Tuğba, Doğan, Gürsoy, Neşelioğlu, Salim, Erel, Özcan
Format: Article
Language:English
Subjects:
Acne
Age
Alopecia
Antioxidants
Baldness
Biochemistry
Body mass index
Cardiovascular disease
Dermatitis
Dermatology
Enzymes
Etiology
Family medical history
Hair
Hair loss
Hemostasis
Homeostasis
Laboratories
Lipid peroxidation
Lipids
Metabolism
Oxidative stress
Pathogenesis
Psoriasis
Ratios
Signal transduction
Sulfur
Thiols
Tıp
Variables
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Summary:Objective: Alopecia areata (AA) is a disorder characterized by non-scarring hair loss, whose etiology involves oxidative stress. We aimed to determine the role of thiol/disulphide levels in AA pathogenesis and to investigate if they can be used as its marker. Materials and Methods: This prospective study included 100 AA patients who presented to dermatology outpatient clinic and 100 healthy controls without any systemic and/or inflammatory dermatological disorder. The control and study groups were compared with respect to native thiol, total thiol, and disulphide levels, and disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol ratios. The relationships between demographic and lesion characteristics, native thiol, total thiol, and disulphide levels, and disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol ratios were studied. Results: The mean age of AA patients was 37.5 years. Fifty-eight (58%) patients were male, and the median body mass index was 24 kg/m2. Median age was significantly higher in the AA group (p
ISSN:2149-9063
2149-9063
DOI:10.4274/meandros.48303