Synthesis of 5-substituted 2-ylidene-1,3-thiazolidin-4-one derivatives and evaluation of their anticancer and antioxidant activities

Novel 5-(aroyl)methyl- and 5-(aroyl)methylen-2-ylidene-1,3-thiazolidin-4-ones have been prepared in high yields using ketene N , S -acetal salts, obtained from phenyl isothiocyanate and propanedinitrile or ethyl cyanoacetate. Several of the newly synthesized 1,3-thiazolidin-4-one derivatives demonst...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2019-10, Vol.55 (10), p.993-1003
Main Authors: Saied, Khaled F., Kandeel, Kamal A., Abdelwahab, Salwa S., Ahmed, Osama M.
Format: Article
Language:English
Subjects:
Anticancer properties
Antioxidants
Cancer
Care and treatment
Chemistry
Chemistry and Materials Science
Derivatives
Organic Chemistry
Pharmacy
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Summary:Novel 5-(aroyl)methyl- and 5-(aroyl)methylen-2-ylidene-1,3-thiazolidin-4-ones have been prepared in high yields using ketene N , S -acetal salts, obtained from phenyl isothiocyanate and propanedinitrile or ethyl cyanoacetate. Several of the newly synthesized 1,3-thiazolidin-4-one derivatives demonstrate high antioxidant and anticancer activities.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-019-02568-5