Efficient one-step synthesis of 3-aryl-2-pyridones from 6-aryl-1,2,4-triazin-5-ones

An efficient method for the synthesis of substituted 2-pyridones based on the aza-Diels–Alder reaction of 1,2,4-triazin-5-ones and dienophiles, 2,5-norbornadiene and 4-(cyclopent-1-en-1-yl)morpholine, is proposed.

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2019-10, Vol.55 (10), p.985-988
Main Authors: Savchuk, Maria I., Shtaitz, Yaroslav K., Kopchuk, Dmitry S., Zyryanov, Grigory V., Eltsov, Oleg S., Pospelova, Tatiana А., Rusinov, Vladimir L., Chupakhin, Oleg N.
Format: Article
Language:English
Subjects:
Aromatic compounds
Chemistry
Chemistry and Materials Science
Diels-Alder reaction
Morpholine
Organic Chemistry
Perampanel
Pharmacy
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Summary:An efficient method for the synthesis of substituted 2-pyridones based on the aza-Diels–Alder reaction of 1,2,4-triazin-5-ones and dienophiles, 2,5-norbornadiene and 4-(cyclopent-1-en-1-yl)morpholine, is proposed.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-019-02566-7