Green synthesis of gold nanoparticles: Preparation, characterization, cytotoxicity, and anti-bacterial activities

[Display omitted] •A novel synthesis of green gold nanoparticles (AuNPs).•Mixtuer of plants extracts is acting as stabilizer and a reducing agent.•Demonstrated cytotoxic activity against HepG-2, HCT-116, and MCF-7 cells.•Showed a highly effective antibacterial activity towards various bacteria strai...

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Bibliographic Details
Published in:Materials letters 2019-12, Vol.256, p.126608, Article 126608
Main Authors: Awad, Manal A., Eisa, Nada E., Virk, Promy, Hendi, Awatif A., Ortashi, Khalid M.O.O., Mahgoub, AbdAlla S.A., Elobeid, Mai A., Eissa, Fahd Z.
Format: Article
Language:English
Subjects:
Acacia nilotica
Anti-bacterial
Antibacterial materials
Anticancer properties
Chemical synthesis
Colon
Cytotoxic activity
Cytotoxicity
Electron microscopy
Energy transmission
Fourier transforms
Gold
Gold nanoparticles
Materials science
Microscopy
Nanoparticles
Nanostructure
Olea europaea
Organic chemistry
Toxicity
‘Green’ synthesis
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Summary:[Display omitted] •A novel synthesis of green gold nanoparticles (AuNPs).•Mixtuer of plants extracts is acting as stabilizer and a reducing agent.•Demonstrated cytotoxic activity against HepG-2, HCT-116, and MCF-7 cells.•Showed a highly effective antibacterial activity towards various bacteria strain.•Synthesized NPs was a promising commercially viable approach for applications in nanomedicine. Synthesis of nanostructures using green chemistry has been popular owing to the exciting properties and innovative applications of these nanostructures. Novel, cost-effective, and eco-friendly gold nanoparticles (Au NPs) were synthesized using a mix of Olea europaea (OE) fruit extract and Acacia nilotica (AN) husk extract. The synthesized Au NPs were characterized by UV–visible spectroscopy, and the average NP size (44.96 nm) was measured by a Zetasizer. A more detailed characterization was performed using Fourier transform infrared spectroscopy, scanning, and transmission electron microscopy and electron microscopy with energy dispersive spectroscopy. The cytotoxicity of the synthesized OEAN Au NPs was evaluated using an MTT assay on breast (MCF-7), colon (TCT-116), and hepatocellular (HCepG-2) carcinoma cells. The antibacterial activity of the synthesized OEAN Au NPs was investigated using a disc diffusion method. The synthesized Au NPs exhibited moderate antibacterial activity against the bacterial strains used and profound anticancer activity against different cell lines used.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2019.126608