Effects of Plasma Surface Treatment on Cell Adhesion to Biocompatible Polymer Brushes

Argon plasma-induced reactions on biocompatible methacrylic polymer brushes were investigated to evaluate the influence on the cell adhesion properties. Polymer brushes of poly(sulfobetaine methacrylate) (PSBMA) and poly(phosphobetaine methacrylate) (PPBMA) were prepared on various substrates using...

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Bibliographic Details
Published in:Journal of Photopolymer Science and Technology 2019/06/24, Vol.32(3), pp.529-533
Main Authors: Sasai, Yasushi, Doi, Naoki, Yamauchi, Yukinori, Kuzuya, Masayuki, Kondo, Shin-ichi
Format: Article
Language:English
Subjects:
Argon
Argon plasma
Biocompatibility
Brushes
Cell adhesion
Cell adhesion & migration
Irradiation
Plasma
Plasma surface treatment
Polymer brushes
Polymers
Polystyrene resins
Substrates
Surface treatment
Zwitterionic polymethacrylates
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Summary:Argon plasma-induced reactions on biocompatible methacrylic polymer brushes were investigated to evaluate the influence on the cell adhesion properties. Polymer brushes of poly(sulfobetaine methacrylate) (PSBMA) and poly(phosphobetaine methacrylate) (PPBMA) were prepared on various substrates using surface-initiated atom transfer radical polymerization techniques. The degradation of PSBMA brushes by Ar plasma irradiation was suppressed than that of PPBMA brushes. This might result from interchain and intrachain interactions of sulfobetaine moieties in PSBMA brushes. Moreover, cell adhesion on plasma-irradiated PSBMA brushes were significantly improved as compared with that to a commercial tissue culture polystyrene dish, suggesting that the resultant surfaces can be used as good scaffolds for cell adhesion.
ISSN:0914-9244
1349-6336
DOI:10.2494/photopolymer.32.529