Fullerenol/iron nanocomposite diminishes doxorubicin-induced toxicity

Fullerenol C 60 (OH) 24 with its spherical shape, symmetrical structure, 1 nm size and the ability to form polyionic nanoparticles in water solution, was used to synthesise a novel nanocomposite made of fullerenol nanoparticles (FNP) and iron ions (Fe 2+ ). The FNP/Fe 2+ nanocomposite was characteri...

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Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2019-11, Vol.21 (11), Article 239
Main Authors: Seke, Mariana, Petrovic, Danijela, Labudovic Borovic, Milica, Borisev, Ivana, Novakovic, Mirjana, Rakocevic, Zlatko, Djordjevic, Aleksandar
Format: Article
Language:English
Subjects:
Buckminsterfullerene
Catalase
Characterization and Evaluation of Materials
Chemistry and Materials Science
Doxorubicin
Ferrous ions
Fullerenes
Heart
Inorganic Chemistry
Iron
Lasers
Liver
Materials Science
Nanocomposites
Nanoparticles
Nanotechnology
Optical Devices
Optics
Oxidative stress
Photonics
Physical Chemistry
Pretreatment
Research Paper
Rodents
Size distribution
Superoxide dismutase
Toxicity
Zeta potential
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Summary:Fullerenol C 60 (OH) 24 with its spherical shape, symmetrical structure, 1 nm size and the ability to form polyionic nanoparticles in water solution, was used to synthesise a novel nanocomposite made of fullerenol nanoparticles (FNP) and iron ions (Fe 2+ ). The FNP/Fe 2+ nanocomposite was characterised by DLS and TEM-EDS analyses which have shown that the size distribution of FNP/Fe 2+ stayed in the same scope as the size distribution of FNP, ranging from 11 to 60 nm. However, Fe 2+ did affect the change of FNP’s zeta potential (− 49.2 mV), shifting it to more positive values (− 30.8 mV). In this study, it was assumed that FNP/Fe 2+ could reduce the toxic effects of doxorubicin (Dox). Male Wistar rats were treated i.p . with FNP/Fe 2+ nanocomposite 1 h prior to Dox treatment. At the subcellular level, the ultrastructural analysis revealed minor alterations sporadically displayed within the heart and liver tissues. Moreover, at the molecular level, the gene expressions analysis of mRNAs for catalase (heart and liver) and MnSOD (only liver) were significantly downregulated, indicating reduction in oxidative stress. Overall, the pretreatment with FNP/Fe 2+ nanocomposite, followed by Dox application, significantly diminished harmful effects of the applied drug on the heart and liver, suggesting the potential protective effect of the nanocomposite on the healthy tissues.
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-019-4681-4