Biological evaluation of bioavailable amphiphilic polymeric conjugate based-on natural products: diosgenin and curcumin

The aim of this study was to design and synthesize amphiphilic supramolecular structures consisting of curcumin and diosgenin-terminated poly (ethylene glycol). Diosgenin, a natural plant extract, has proven to possess significant biological activities such as anti-tumor, anti-diabetes, anti-inflamm...

Full description

Saved in:
Bibliographic Details
Published in:International journal of polymeric materials 2020-01, Vol.69 (2), p.73-84
Main Authors: Ilkar Erdagi, Sevinc, Uyanik, Cavit
Format: Article
Language:English
Subjects:
Alzheimer's disease
Anticancer
Anticancer properties
Bioavailability
Biotechnology
Breast cancer
Conjugates
curcumin
cytotoxicity
diosgenin
Ethylene glycol
Fibroblasts
fluorescence
Natural products
polymeric micelle
Solubility
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to design and synthesize amphiphilic supramolecular structures consisting of curcumin and diosgenin-terminated poly (ethylene glycol). Diosgenin, a natural plant extract, has proven to possess significant biological activities such as anti-tumor, anti-diabetes, anti-inflammatory, anti-cancer, and effect on improving memory in Alzheimer's disease. While curcumin, the main compound of the spice turmeric, is one of the natural products that exhibits a wide range of pharmacological activities. But poor water solubility and low bioavailability of these materials have limited their clinical applications. Herein, novel amphiphilic conjugate poly (ethylene glycol) diosgenin-curcumin with improved solubility and bioavailability were developed. Cytotoxicity/anticancer effects on human fibroblast cells and human breast cancer cells are investigated with prospective potential applications in cancer therapeutics. The synthesized polymeric conjugate demonstrated non-toxic to L929 (fibroblast) cell lines but highly toxic to MCF-7 breast cancer cell lines.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2018.1539989