Effects of long-term treatment with antipsychotics on serum leptin levels

Abnormal regulation of the adipocyte-derived hormone leptin could play a role in body weight gain induced by antipsychotics. To study the effects of long-term antipsychotic treatment on leptin levels in patients with schizophrenia. Serum leptin levels were determined in 59 out-patients with chronic...

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Bibliographic Details
Published in:British journal of psychiatry 2001-07, Vol.179 (1), p.59-62
Main Authors: Herrán, Andrés, García-Unzueta, María Teresa, Amado, José Antonio, De La Maza, María Teresa, Álvarez, Concepción, Vázquez-Barquero, José Luis
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Antipsychotic Agents - adverse effects
Antipsychotics
Body mass index
Body weight
Body weight gain
Chronic Disease
Chronic illnesses
Clinical variables
Female
Hormones
Humans
Induced
Leptin
Leptin - blood
Long term
Male
Mental disorders
Olanzapine
Patients
Psychiatry
Psychotropic drugs
Schizophrenia
Schizophrenia - blood
Schizophrenia - drug therapy
Serum
Variables
Variance analysis
Weight gain
Weight Gain - drug effects
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Summary:Abnormal regulation of the adipocyte-derived hormone leptin could play a role in body weight gain induced by antipsychotics. To study the effects of long-term antipsychotic treatment on leptin levels in patients with schizophrenia. Serum leptin levels were determined in 59 out-patients with chronic schizophrenia and in the same number of healthy subjects controlled by gender, age and body mass index. Leptin levels did not differ between patients and controls. Leptin levels in patients with schizophrenia correlated with weight gain, even after controlling for current weight, but did not show any association with clinical variables. Antipsychotic class tended to exert different effects over leptin levels (among atypicals, olanzapine induced a greater increase). Elevation of leptin levels induced by chronic antipsychotic treatment can be attributed to weight gain, but other mechanisms could be involved.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.179.1.59