Transition‐Metal‐Free Alkylation/Arylation of Benzoxazole via Tf2O‐Activated‐Amide

A transition‐metal‐free approach to the alkylation/arylation of benzoxazole was developed by employing Tf2O‐activated‐amide as the alkylating/arylating reagent. The mild reaction conditions, and particularly insensitivity to air and water, further enhance the synthetic potential in pharmaceutical sy...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2019-11, Vol.361 (22), p.5217-5222
Main Authors: Niu, Zhi‐Jie, Li, Lian‐Hua, Liu, Xue‐Yuan, Liang, Yong‐Min
Format: Article
Language:English
Subjects:
Alkylation
alkylation/arylation
amide
benzoxazole, metal-free
Reagents
triflic anhydride
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Summary:A transition‐metal‐free approach to the alkylation/arylation of benzoxazole was developed by employing Tf2O‐activated‐amide as the alkylating/arylating reagent. The mild reaction conditions, and particularly insensitivity to air and water, further enhance the synthetic potential in pharmaceutical synthesis.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201901078