Sulfoxonium Ylides as Carbene Precursors: Rhodium(III)‐Catalyzed Sequential C−H Functionalization, Selective Enol Oxygen‐Atom Nucleophilic Addition, and Hydrolysis

Herein, we report a protocol for Rh(III)‐catalyzed annulation reactions between oxazolines and sulfoxonium ylides via a sequence involving C−H activation, selective enol oxygen‐atom nucleophilic addition, and hydrolysis. This practical, operationally simple protocol has a wide substrate range, excel...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2019-11, Vol.361 (22), p.5272-5276
Main Authors: Huang, Yuanqiong, Lyu, Xueli, Song, Hongjian, Wang, Qingmin
Format: Article
Language:English
Subjects:
Chemical reactions
Hydrolysis
nucleophilic addition
oxazolines
Regioselectivity
Rhodium
Substrates
ylides
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Summary:Herein, we report a protocol for Rh(III)‐catalyzed annulation reactions between oxazolines and sulfoxonium ylides via a sequence involving C−H activation, selective enol oxygen‐atom nucleophilic addition, and hydrolysis. This practical, operationally simple protocol has a wide substrate range, excellent regioselectivity, and moderate to good yields.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201900861