Patterns of neurocognitive impairment in first-episode bipolardisorder and schizophrenia

BackgroundResearching psychotic disorders in unison rather than as separatediagnostic groups is widely advocated, but the viability of such anapproach requires careful consideration from a neurocognitiveperspective.AimsTo describe cognition in people with bipolar disorder and schizophreniaand to exa...

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Bibliographic Details
Published in:British journal of psychiatry 2009-07, Vol.195 (1), p.67-72
Main Authors: Barrett, Suzanne L, Mulholland, Ciaran C, Cooper, Stephen J, Rushe Teresa M
Format: Article
Language:eng ; jpn
Subjects:
Bipolar disorder
Cognition
Cognitive ability
Cognitive impairment
Emotional behavior
Executive function
Localization
Memory
Mental disorders
Negative symptoms
Neurocognition
Patients
Psychiatry
Psychosis
Psychotropic drugs
Response inhibition
Schizophrenia
Variability
Viability
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Summary:BackgroundResearching psychotic disorders in unison rather than as separatediagnostic groups is widely advocated, but the viability of such anapproach requires careful consideration from a neurocognitiveperspective.AimsTo describe cognition in people with bipolar disorder and schizophreniaand to examine how known causes of variability in individual'sperformance contribute to any observed diagnostic differences.MethodNeurocognitive functioning in people with bipolar disorder(n = 32), schizophrenia (n = 46) andhealthy controls (n = 67) was compared using analysis ofcovariance on data from the Northern Ireland First Episode PsychosisStudy.ResultsThe bipolar disorder and schizophrenia groups were most impaired on testsof memory, executive functioning and language. The bipolar groupperformed significantly better on tests of response inhibition, verbalfluency and callosal functioning. Between-group differences could beexplained by the greater proclivity of individuals with schizophrenia toexperience global cognitive impairment and negative symptoms.ConclusionsParticular impairments are common to people with psychosis and may proveuseful as endophenotypic markers. Considering the degree of individuals'global cognitive impairment is critical when attempting to understandpatterns of selective impairment both within and between these diagnosticgroups.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.bp.108.054874