Synthesis of nanoparticle-hydrogel composites based on crosslinked by Al ions poly(sodium acrylate), Fe2O3 and γ-AlOOH

In the present study, novel nanoparticle-hydrogel composites have been synthesized as a potential hemostatic wound-healing agent. Poly(sodium acrylate) has been cross-linked by aluminum ions, forming physical hydrogel, which was used as a matrix, while nanoscale boehmite (γ-AlOOH) and Fe2O3 were use...

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Main Authors: Rubtsov, K. V., Kondranova, A. M., Lozhkomoev, A. S., Kazantsev, S. O., Mamonova, E. V., Gavrilova, L. O., Sadovoy, M. A.
Format: Conference Proceeding
Language:English
Subjects:
Aluminum
Boehmite
Crosslinking
Fillers
Hydrogels
Nanocomposites
Nanoparticles
Oxidation
Polymer matrix composites
Sodium
Toxicity
Wound healing
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Summary:In the present study, novel nanoparticle-hydrogel composites have been synthesized as a potential hemostatic wound-healing agent. Poly(sodium acrylate) has been cross-linked by aluminum ions, forming physical hydrogel, which was used as a matrix, while nanoscale boehmite (γ-AlOOH) and Fe2O3 were used as fillers. A new approach to hydrogel synthesis has been proposed. This technique involves oxidation of aluminum nanoparticles suspended in poly(sodium acrylate) concentrated solution, thus, generating aluminum ions, which serve as a cross-linking agent, forming hydrogel network. In order to obtain nanoparticle-hydrogel composites, nanoscale fillers were added to polymer solution prior to hydrogel formation. MTT-assay, performed for analyzing the cytotoxic effects of all synthesized nanocomposites, revealed its non-toxicity at the concentrations 0.1 – 0.00625 mg/ml.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.5132165