Pumping Patterns and Work Done during Peristalsis in Finite-length Elastic Tubes

Balloon dilation catheters are often used to quantify the physiological state of peristaltic activity in tubular organs and comment on their ability to propel fluid which is important for healthy human function. To fully understand this system's behavior, we analyzed the effect of a solitary pe...

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Bibliographic Details
Published in:arXiv.org 2021-01
Main Authors: Acharya, Shashank, Kou, Wenjun, Halder, Sourav, Carlson, Dustin A, Kahrilas, Peter J, Pandolfino, John E, Patankar, Neelesh A
Format: Article
Language:English
Subjects:
Catheters
Computer simulation
Dilation
Human behavior
Internal flow
Laminar flow
One dimensional models
Organs
Pumping
Reduced order models
Three dimensional models
Tubes
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Summary:Balloon dilation catheters are often used to quantify the physiological state of peristaltic activity in tubular organs and comment on their ability to propel fluid which is important for healthy human function. To fully understand this system's behavior, we analyzed the effect of a solitary peristaltic wave on a fluid-filled elastic tube with closed ends. A reduced order model that predicts the resulting tube wall deformations, flow velocities and pressure variations is presented. This simplified model is compared with detailed fluid-structure 3D immersed boundary simulations of peristaltic pumping in tube walls made of hyperelastic material. The major dynamics observed in the 3D simulations were also displayed by our 1D model under laminar flow conditions. Using the 1D model, several pumping regimes were investigated and presented in the form of a regime map that summarizes the system's response for a range of physiological conditions. Finally, the amount of work done during a peristaltic event in this configuration was defined and quantified. The variation of elastic energy and work done during pumping was found to have a unique signature for each regime. An extension of the 1D model is applied to enhance patient data collected by the device and find the work done for a typical esophageal peristaltic wave. This detailed characterization of the system's behavior aids in better interpreting the clinical data obtained from dilation catheters. Additionally, the pumping capacity of the esophagus can be quantified for comparative studies between disease groups.
ISSN:2331-8422
DOI:10.48550/arxiv.1911.09286