Flow‐based reactor design for the continuous production of polymeric nanoparticles

Polymeric nanoparticles (NPs) are versatile and effective drug delivery systems (DDS) that can be produced via nanoprecipitation of block copolymers. Yet, translation into clinical products has been limited. Thus, methods for NP production that enable rapid formulation screening and continuous produ...

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Bibliographic Details
Published in:AIChE journal 2019-12, Vol.65 (12), p.n/a
Main Authors: Bovone, Giovanni, Guzzi, Elia A., Tibbitt, Mark W.
Format: Article
Language:English
Subjects:
biomedical engineering
Block copolymers
Continuous production
controlled release formulations
Drug delivery
Drug delivery systems
Microfluidic devices
microfluidics
Nanoparticles
nanotechnology
Polyethylene glycol
Polylactic acid
Process engineering
Production methods
Reactor design
Screening
self assembly
Solvents
System effectiveness
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Summary:Polymeric nanoparticles (NPs) are versatile and effective drug delivery systems (DDS) that can be produced via nanoprecipitation of block copolymers. Yet, translation into clinical products has been limited. Thus, methods for NP production that enable rapid formulation screening and continuous production are needed. Toward this end, we engineered a coaxial jet mixer (CJM) for controlled and continuous nanoprecipitation in flow. The CJM enabled continuous assembly of poly(ethylene glycol)‐block‐polylactide NPs with various co‐solvents and was compared to batch nanoprecipitation. Other fabricated microfluidic devices were suitable for small scale formulation screening but more limited in scalable and continuous processes. In contrast, the CJM was tolerant to all water‐miscible solvents tested, enabled formulation screening, and scalable production of NPs and DDS. In total, the CJM provides a complementary approach to the process engineering of polymeric NP formation that can be used broadly for formulation screening and production.
ISSN:0001-1541
1547-5905
DOI:10.1002/aic.16840