HLA-C07 in axial spondyloarthritis: data from the GermanSpondyloarthritis Inception Cohort and the Spondyloarthritis Caught Earlycohort

We aimed to assess the mRNA expression of MHC class 1-related molecules in ankylosing spondylitis (AS) patients vs healthy controls (HCs) and, subsequently, if the absence of HLA-C*07 is associated with genetic susceptibility to axial spondyloarthritis (axSpA). HLA-C*07 was assessed in (a) an explor...

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Published in:Genes and immunity 2019-11, Vol.20 (8), p.671-677
Main Authors: de Winter Janneke J, Blijdorp, Iris C, de Jong Henriëtte M, Sauter Jürgen, Schmidt, Alexander H, van Gaalen Floris A, van der Heijde Désirée, Poddubnyy Denis, Yeremenko, Nataliya G, van de Sande Marleen G, Baeten, Dominique L
Format: Article
Language:English
Subjects:
Ankylosing spondylitis
Arthritis
Back pain
Gene expression
Histocompatibility antigen HLA
Inflammatory diseases
Major histocompatibility complex
Rheumatic diseases
Spondylitis
Stem cells
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Summary:We aimed to assess the mRNA expression of MHC class 1-related molecules in ankylosing spondylitis (AS) patients vs healthy controls (HCs) and, subsequently, if the absence of HLA-C*07 is associated with genetic susceptibility to axial spondyloarthritis (axSpA). HLA-C*07 was assessed in (a) an exploratory cohort of 24 AS patients vs 40 HCs, (b) a confirmatory cohort of 113 AS patients and 83 non-radiographic axSpA patients from the GErman SPondyloarthritis Inception Cohort (GESPIC) vs 134,528 German potential stem cell donors, and (c) an early back pain cohort with 94 early axSpA patients vs 216 chronic back pain (CBP) patients from the SPondyloArthritis Caught Early (SPACE) cohort. In the exploratory cohort, 79% of the AS patients were HLA-C*07 negative compared to 35% of the HCs (p 
ISSN:1466-4879
1476-5470
DOI:10.1038/s41435-019-0061-4