Interaction between cholesterol and glucose metabolism during dietary carbohydrate modification in subjects with the metabolic syndrome

• Published in: The American journal of clinical nutrition 2006-12, Vol.84 (6), p.1385-1392
• Main Authors: Hallikainen, Maarit, Toppinen, Leena, Mykkänen, Hannu, Ågren, Jyrki J, Laaksonen, David E, Miettinen, Tatu A, Niskanen, Leo, Poutanen, Kaisa S, Gylling, Helena
• Format: Article
• Language: English
• Subjects: Adult; Aged; Area Under Curve; Avena; Biological and medical sciences; Blood Glucose - metabolism; carbohydrate metabolism; Carbohydrates; Cholesterol; Cholesterol - biosynthesis; Cholesterol - metabolism; Desmosterol; Diet; dietary carbohydrate; Dietary Carbohydrates - administration & dosage; Dietary Carbohydrates - classification; Dietary Carbohydrates - metabolism; experimental diets; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; glucose; Glycemic Index; human nutrition; Humans; Insulin - metabolism; Insulin Secretion; Intestinal Absorption; lipid metabolism; Male; men; Metabolic syndrome; Metabolic Syndrome - diet therapy; Metabolic Syndrome - metabolism; Metabolism; Middle Aged; Nutrition; pasta; randomized clinical trials; rye products; Secale; Solanum tuberosum; Triticum; Vertebrates: anatomy and physiology, studies on body, several organs or systems; women
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/84.6.1385

BACKGROUND: Carbohydrate modification based on rye bread and pasta enhances early insulin secretion in subjects with the metabolic syndrome. OBJECTIVE: Because the actions of insulin and cholesterol metabolism are interrelated, the question is raised of whether it is possible to alter cholesterol metabolism by means of dietary carbohydrate modification. DESIGN: We investigated the 12-wk effects of dietary carbohydrate modification on cholesterol synthesis and absorption by measuring the ratios of surrogate markers of precursor (cholestenol, desmosterol, and lathosterol) and absorption (cholestanol and plant sterols) sterols to cholesterol and their association to glucose metabolism in 74 subjects with the metabolic syndrome. The subjects were randomly assigned to diets with rye bread and pasta (RPa) or oat, wheat bread, and potato (OWPo) as the main carbohydrate source (34% and 37% of energy intake, respectively). RESULTS: During the study, serum cholesterol concentrations remained unchanged. Cholesterol synthesis was lower (6-10% for cholestenol and lathosterol; P < 0.05) and absorption higher (9%; P < 0.05 for sitosterol) with the OWPo diet than at baseline. With the RPa diet, cholesterol absorption was lower and synthesis higher than with the OWPo diet. The increment in the glucose area under the curve with the RPa diet was positively related to baseline cholesterol synthesis (eg, lathosterol; r = 0.480, P < 0.05) and negatively to absorption (for cholestanol; r = -0.520, P < 0.05). In the combined group, the changes in the cholestanol ratio and the insulinogenic index were interrelated (r = -0.464, P < 0.001). CONCLUSIONS: Carbohydrate modifications had dissimilar effects on cholesterol metabolism. Consumption of RPa, as compared with OWPo, may be clinically more favorable because it seems to inhibit the absorption of cholesterol, a factor crucial in the development of arterial atherosclerosis.