MolCom system with downlink/uplink biocyber interface for Internet of Bio‐NanoThings

• Published in: International journal of communication systems 2020-01, Vol.33 (1), p.n/a
• Main Authors: Abd El‐atty, Saied M., Bidar, Reda, El‐Rabaie, El‐Sayed M.
• Format: Article
• Language: English
• Subjects: Actuators; Biochemistry; biocyber interface; Change detection; Channel capacity; Computer simulation; Decision analysis; Drug delivery systems; Embedded sensors; Embedded systems; Energy transfer; Epidemics; Fluorescence; FRET; Internet; IoBNT; molecular communication (MolCom); nanomachine; nanonetwork; Performance evaluation; Wireless communication systems; Wireless communications
• ISSN: 1074-5351; 1099-1131
• DOI: 10.1002/dac.4171

Summary Inspired by wireless communication systems, we propose a feasible downlink/uplink biocyber interface for the expected targeted drug delivery system based on Internet of Biological NanoThing (IoBNT) paradigm. The downlink/uplink biocyber interface of IoBNT comprises Fluorescence Resonance Energy Transfer (FRET) and Molecular Communication (MolCom) technology. On the downlink (from Internet to targeted nanonetwork), the biocyber interface transduces electromagnetic (EM) signal to biochemical signals, and thus with the help of mobile MolCom system based on FRET nanocommunication, the drug information delivers to the diseased cell within the targeted intrabody nanonetwork. On the uplink, the MolCom system consists of embedded sensor/actuator nanonetwork to detect the biochemical changes in the targeted cell, and hence biocyber interface transduces the biochemical signal to EM signal. As a result, the paradigm of IoBNT responses by proper functions to these changes according to the decision of medical health care. The performance analysis of the proposed IoBNT system is numerically investigated through MolCom system‐based FRET, while the performance evaluation is evaluated by employing spreading epidemic scheme in terms of successful probability of drug delivery, channel capacity, average drug‐delivery time, and throughput. The simulation results show that the proposed IoBNT is a promising paradigm for smart drug delivery system, and its performance is mainly based on the nanostructure and the characteristic of molecular nanomachines in the targeted nanonetwork. IoBNT paradigm‐based downlink/uplink MolCom system: On the downlink (from Internet to targeted nanonetwork), the biocyber transduces electromagnetic (EM) signal to biochemical signals, and thus with the help of mobile MolCom system based on FRET nanocommunication, the drug information delivers to the diseased cell within the targeted intrabody nanonetwork. On the uplink, the MolCom system consists of embedded sensor/actuator nanonetwork to detect the biochemical changes in the targeted cell, and hence biocyber interface transduces the biochemical signal to EM signal.