Multiple emulsions as effective platforms for controlled anti-cancer drug delivery

Developing pH-responsive multiple emulsion platforms for effective glioblastoma multiforme therapy with reduced toxicity, a drug release study and modeling. Cancer cell line: U87 MG, multiple emulsions with pH-responsive biopolymer and encapsulated doxorubicin (DOX); preparation of multiple emulsion...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2017-09, Vol.12 (18), p.2183-2197
Main Authors: Dluska, Ewa, Markowska-Radomska, Agnieszka, Metera, Agata, Tudek, Barbara, Kosicki, Konrad
Format: Article
Language:English
Subjects:
Acids
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Aqueous solutions
Biochemistry
Biomedical materials
Brain cancer
Brain Neoplasms - drug therapy
Cancer therapies
cancer/oncology
Cell Line, Tumor
Cell Survival
Chemotherapy
Computer Simulation
controlled drug release
Cytotoxicity
Dehydrogenases
doxorubicin
Doxorubicin - administration & dosage
Doxorubicin - chemistry
drug delivery platform
Drug Delivery Systems
Drug Liberation
drug release modeling
Emulsions - chemistry
Glioblastoma - drug therapy
glioblastoma multiforme
Humans
Hydrogen-Ion Concentration
Ligands
multiple emulsion
Nanoparticles
Particle Size
Quantum dots
Surface Properties
tumor-specific pH-responsive emulsion
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Summary:Developing pH-responsive multiple emulsion platforms for effective glioblastoma multiforme therapy with reduced toxicity, a drug release study and modeling. Cancer cell line: U87 MG, multiple emulsions with pH-responsive biopolymer and encapsulated doxorubicin (DOX); preparation of multiple emulsions in a Couette-Taylor flow biocontactor, release study of DOX (fluorescence intensity analysis), cytotoxicity study (alamarBlue cell viability assay) and numerical simulation of DOX release rates. The multiple emulsions offered a high DOX encapsulation efficiency (97.4 ± 1%) and pH modulated release rates of a drug. Multiple emulsions with a low concentration of DOX (0.02 μM) exhibited broadly advanced cell (U87 MG) cytotoxicity than free DOX solution used at the same concentration. Emulsion platforms could be explored for potential delivery of chemotherapeutics in glioblastoma multiforme therapy.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2017-0112