Drug delivery to the eye: what benefits do nanocarriers offer?

Ocular drug delivery has seen several advances in the past few decades, with respect to new drugs, improved formulations, targeted delivery, as well as exploration of new routes of drug administration. New materials have been explored for encasing existing drugs, which can enhance treatment by incre...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2017-03, Vol.12 (6), p.683-702
Main Authors: Joseph, Rini Rachel, Venkatraman, Subbu S
Format: Article
Language:English
Subjects:
anterior segment delivery
Bioavailability
Biodegradation
Cataracts
Chronic illnesses
Diabetes
Diabetic retinopathy
Drug Carriers - chemistry
Drug Carriers - therapeutic use
Drug Delivery Systems
Edema
Eye - drug effects
Eye - pathology
fate and ocular disposition
Feasibility studies
Glaucoma
Humans
liposomes
Macular degeneration
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - therapeutic use
Nanotechnology - trends
posterior segment delivery
Retina
sustained delivery
Viscosity
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Summary:Ocular drug delivery has seen several advances in the past few decades, with respect to new drugs, improved formulations, targeted delivery, as well as exploration of new routes of drug administration. New materials have been explored for encasing existing drugs, which can enhance treatment by increasing bioavailability, decreasing toxicity, providing better tissue adherence, targeted delivery as well as increased duration of action. The challenges and requirements are different for the anterior and posterior ocular segments. This review summarizes the recent advances in sustained ocular therapy, both to the anterior and posterior segments, which have been made possible, thanks to nanotechnology. We also discuss the distribution and fate of these nanocarriers themselves, postadministration, as well as clearance from ocular tissues.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2016-0379