Impact of endotoxin on UCP homolog mRNA abundance, thermoregulation, and mitochondrial proton leak kinetics

Linking tissue uncoupling protein (UCP) homolog abundance with functional metabolic outcomes and with expression of putative genetic regulators promises to better clarify UCP homolog physiological function. A murine endotoxemia model characterized by marked alterations in thermoregulation was employ...

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2000-08, Vol.42 (2), p.E433-E446
Main Authors: XING XIAN YU, BARGER, J. L, BOYER, B. B, BRAND, M. D, GUOHUA PAN, ADAMS, S. H
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Genes
Kinetics
Liver
Metabolism
Muscular system
Proteins
Ribonucleic acid
RNA
Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Linking tissue uncoupling protein (UCP) homolog abundance with functional metabolic outcomes and with expression of putative genetic regulators promises to better clarify UCP homolog physiological function. A murine endotoxemia model characterized by marked alterations in thermoregulation was employed to examine the association between heat production, UCP homolog expression, and mitochondrial proton leak ("uncoupling").
ISSN:0193-1849
1522-1555