Self-healable hyaluronic acid/chitosan polyelectrolyte complex hydrogels and multilayers

[Display omitted] •Hyaluronic acid and chitosan assembled as hydrogels and nanometric multilayers.•Formation of the complexes was demonstrated in hydrogels and multilayers.•HA/CHI hydrogels and multilayers showed self-healing properties in a few minutes.•Self-healed hydrogels maintained the rheologi...

Full description

Saved in:
Bibliographic Details
Published in:European polymer journal 2019-11, Vol.120, p.109268, Article 109268
Main Authors: Barroso, Nagore, Guaresti, Olatz, Pérez-Álvarez, Leyre, Ruiz-Rubio, Leire, Gabilondo, Nagore, Vilas-Vilela, José Luis
Format: Article
Language:English
Subjects:
Biomedical materials
Chitosan
Differential scanning calorimetry
Diffraction
Fourier transforms
Hyaluronic acid
Hydrogels
Infrared spectroscopy
Multilayers
Polyelectrolyte complexes
Polyelectrolytes
Polyethylene terephthalate
Polysaccharides
Rheological properties
Scanning electron microscopy
Self-healing
Studies
Thermogravimetric analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •Hyaluronic acid and chitosan assembled as hydrogels and nanometric multilayers.•Formation of the complexes was demonstrated in hydrogels and multilayers.•HA/CHI hydrogels and multilayers showed self-healing properties in a few minutes.•Self-healed hydrogels maintained the rheological properties of the initial material. In this work, polyelectrolyte complexes (PEC) were obtained in form of nanometric polyelectrolyte multilayers (PEMs) and macroscopic hydrogels by electrostatic interactions between two natural polysaccharides: hyaluronic acid (HA) and chitosan (CHI). PEM was developed onto poly(ethylene terephthalate) (PET) surface by layer-by-layer approach. The characterization of both systems was carried out simultaneously by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), X ray diffraction (XRD), thermogravimetric analysis (TGA) and transmission and scanning electronic microscopy (TEM and SEM). The rheological properties of PEC hydrogels were also analysed. The formation of the complexes was demonstrated due to electrostatic interactions, which in turn resulted being responsible for intrinsic self-healing ability. This is a highly demanded property in reducing replacements costs. Both, PEC hydrogels and multilayers showed self-healing properties within few minutes, this fact proves the versatility of HA/CHI complexes to easily obtain different forms of self-healable materials interesting as functional biomedical supports and coatings.
ISSN:0014-3057
1873-1945
DOI:10.1016/j.eurpolymj.2019.109268