Synthesis, spectral characterization, and biological evaluation of imidazole‐substituted pyridine‐2‐amine and benzo‐substituted imidazole‐2‐amine

• Published in: Journal of the Chinese Chemical Society (Taipei) 2019-12, Vol.66 (12), p.1700-1707
• Main Authors: Mahaboob Basha, Shaik, Varalakshmi, Mavallur, Thaslim Basha, Shaik, Venkataramaiah, Chintha, Syed Shafi, Suban, Naga Raju, Chamarthi, Rajendra, Wudayagiri
• Format: Article
• Language: English
• Subjects: Amines; Antiinfectives and antibacterials; antioxidant and antimicrobial activities; Antioxidants; Aromatic compounds; aryl/alkyl isocyanates; Imidazole; Isopropanol; NMR; Nuclear magnetic resonance; Substitutes
• ISSN: 0009-4536; 2192-6549
• DOI: 10.1002/jccs.201800461

A series of new imidazole‐substituted pyridine‐2‐amine and benzo‐substituted imidazol‐2‐amine 3–12 were synthesized by treating various amines 1(a–d) with alkyl/aryl isothiocyanate 2(a‐c) at 60–90°C in isopropyl alcohol without using any catalyst with high yields. The structures of all the newly synthesized compounds were characterized using IR, NMR (1H, 13C), mass, and elemental analyses. All the newly synthesized compounds were screened for their in vitro antioxidant and antimicrobial activities to understand their biological potency. All the title compounds exhibited good antioxidant and antimicrobial activities in vitro when compared to the standard drugs. A series of new imidazole substituted pyridine‐2‐amine and benzo substituted imidazole‐2‐amine has been synthesized by treating various diamines with alkyl/aryl isothiocyanate in isopropylalcohol without using any catalyst with high yields. These compounds were screened for their antimicrobial and antioxidant activities.