Endothelial cell nitric oxide inhibits aldosterone synthesis in zona glomerulosa cells : modulation by oxygen

The regulation of aldosterone synthesis by endogenous nitric oxide (NO) was examined in cultured cells of the adrenal cortex. Endothelial NO synthase (eNOS) was detected by Western blot in cultured adrenal endothelial cells (ECs) but not in zona glomerulosa (ZG) cells or adrenal fibroblasts.

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2000-10, Vol.42 (4), p.E846-E854
Main Authors: HANKE, Craig J, CAMPBELL, William B
Format: Article
Language:English
Subjects:
Adrenals. Interrenals
Adrenomedullary hormones. Regulation
Biological and medical sciences
Cells
Fundamental and applied biological sciences. Psychology
Oxygen
Potassium
Vertebrates: endocrinology
Online Access:Get full text
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Description
Summary:The regulation of aldosterone synthesis by endogenous nitric oxide (NO) was examined in cultured cells of the adrenal cortex. Endothelial NO synthase (eNOS) was detected by Western blot in cultured adrenal endothelial cells (ECs) but not in zona glomerulosa (ZG) cells or adrenal fibroblasts.
ISSN:0193-1849
1522-1555