Fasting for 72 h increases intramyocellular lipid content in nondiabetic, physically fit men

The purpose of this study was to determine changes in intramyocellular lipid (IMCL) content in the vastus lateralis of nondiabetic, physically fit males over 72 h of fasting. Six men, mean age 35 yr (range 23-55 yr), body mass index 23.7 kg/m2 (21.2-27.4 kg/m2), undertook a water-only fast for 84 h....

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Published in:American journal of physiology: endocrinology and metabolism 2002-12, Vol.46 (6), p.E1185-E1191
Main Authors: STANNARD, S. R, THOMPSON, M. W, FAIRBAIRN, K, HUARD, B, SACHINWALLA, T, THOMPSON, C. H
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fasting
Fatty acids
Fundamental and applied biological sciences. Psychology
Insulin
Metabolism
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
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Summary:The purpose of this study was to determine changes in intramyocellular lipid (IMCL) content in the vastus lateralis of nondiabetic, physically fit males over 72 h of fasting. Six men, mean age 35 yr (range 23-55 yr), body mass index 23.7 kg/m2 (21.2-27.4 kg/m2), undertook a water-only fast for 84 h. Vastus lateralis IMCL content was determined using proton magnetic resonance spectroscopy after 12 and 84 h of fasting. Venous blood was sampled at 12-h intervals throughout the fast. IMCL-(CH2)n/water and IMCL-(CH2)n/total creatine ratios increased from 0.00623 plus or minus 0.00065 to 0.0142 plus or minus 0.0015 (P = 0.002) and 6.82 plus or minus 0.87 to 14.96 plus or minus 1.73 (P = 0.001), respectively. Plasma free fatty acid (FFA), serum triglyceride, and whole blood 3-hydroxybutyrate concentrations increased (P < 0.001,
ISSN:0193-1849
1522-1555