Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action

Leptin decreases visceral fat (VF) and increases peripheral and hepatic insulin action. Here, we generated similar decreases in VF using leptin (Lep), Beta2-adrenoreceptor agonism (Beta3), or food restriction (FR) and asked whether insulin action would be equally improved.

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 1999-08, Vol.40 (2), p.E291-E298
Main Authors: BARZILAI, N, LI SHE, LISEN LIU, JIALI WANG, MEIZU HU, VUGUIN, P, ROSSETTI, L
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Glucose
Insulin
Medical sciences
Metabolic diseases
Obesity
Online Access:Get full text
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Description
Summary:Leptin decreases visceral fat (VF) and increases peripheral and hepatic insulin action. Here, we generated similar decreases in VF using leptin (Lep), Beta2-adrenoreceptor agonism (Beta3), or food restriction (FR) and asked whether insulin action would be equally improved.
ISSN:0193-1849
1522-1555