Glucocorticoids abate p70S6k and eif4e function in L6 skeletal myoblasts

The catabolic properties of glucocorticoid hormones are largely attributable to dual regulation of protein degradation and synthesis. With regard to the latter, glucocorticoids modulate the translational machinery, namely that component functional in translation initiation.

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2000-07, Vol.42 (1), p.E74-E82
Main Authors: JAMEEL SHAH, O, KIMBALL, S. R, JEFFERSON, L. S
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Hormones
Proteins
Skeleton and joints
Vertebrates: osteoarticular system, musculoskeletal system
Online Access:Get full text
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Description
Summary:The catabolic properties of glucocorticoid hormones are largely attributable to dual regulation of protein degradation and synthesis. With regard to the latter, glucocorticoids modulate the translational machinery, namely that component functional in translation initiation.
ISSN:0193-1849
1522-1555