Inhibition of salivary secretion by lipopolysaccharide : Possible role of prostaglandins

Inducib le (calcium-independent) nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) are important in the regulation of the function of different organs during infection. A single dose of lipopolysaccharide (LPS; 5 mg/kg ip) within 6 h increased NOS activity (20%) and prostaglandin E (PGE) con...

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2001-08, Vol.44 (2), p.E405-E411
Main Authors: LOMNICZI, A, MOHN, C, FALETTI, A, FRANCHI, A, MCCANN, S. M, RETTORI, V, ELVERDIN, J. C
Format: Article
Language:English
Subjects:
Biological and medical sciences
Body fluids
Endocrine system
General aspects
Human infectious diseases. Experimental studies and models
Infectious diseases
Medical sciences
Metabolism
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Summary:Inducib le (calcium-independent) nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) are important in the regulation of the function of different organs during infection. A single dose of lipopolysaccharide (LPS; 5 mg/kg ip) within 6 h increased NOS activity (20%) and prostaglandin E (PGE) content (100%) in submandibular glands (SMG) and blocked stimulated salivary secretion in adult male rats.
ISSN:0193-1849
1522-1555