Fetal growth and the physiological control of glucose tolerance in adults : a minimal model analysis

Although there is now substantial evidence linking low birthweight with impaired glucose tolerance and type 2 diabetes in adult life, the extent to which reduced fetal growth is associated with impaired insulin sensitivity, defective insulin secretion, or a combination of both factors is not clear.

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2000-04, Vol.41 (4), p.E700-E706
Main Authors: FLANAGAN, D. E, MOORE, V. M, GODSLAND, I. F, COCKINGTON, R. A, ROBINSON, J. S, PHILLIPS, D. I. W
Format: Article
Language:English
Subjects:
Babies
Biological and medical sciences
Cellular biology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Glucose
Insulin
Medical sciences
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Description
Summary:Although there is now substantial evidence linking low birthweight with impaired glucose tolerance and type 2 diabetes in adult life, the extent to which reduced fetal growth is associated with impaired insulin sensitivity, defective insulin secretion, or a combination of both factors is not clear.
ISSN:0193-1849
1522-1555