4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle

Maintenance of cellular protein stores in skeletal muscle depends on a tightly regulated synthesis-degradation equilibrium that is conditionally modulated under an extensive range of physiological nad pathophysiological circumstances. Recent studies have stablished the insitiation phase of mRNA tran...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2000-10, Vol.42 (4), p.E715-E729
Main Authors: SHAH, O. Jameel, ANTHONY, Joshua C, KIMBALL, Scot R, JEFFERSON, Leonard S
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Hormones
Molecular and cellular biology
Molecular genetics
Muscular system
Nutrition
Proteins
Translation. Translation factors. Protein processing
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Maintenance of cellular protein stores in skeletal muscle depends on a tightly regulated synthesis-degradation equilibrium that is conditionally modulated under an extensive range of physiological nad pathophysiological circumstances. Recent studies have stablished the insitiation phase of mRNA translation as apivotal site of regulation for global rates of protein synthesis, as well as a site through which the synthesis of specific proteins is controlled.
ISSN:0193-1849
1522-1555