Glucocorticoids oppose translational control by leucine in skeletal muscle

Glucocorticoids comprise an important class of hormaonal mediators of fuel and protein homeostasis in normal and pathological scenarios. In skeletal muscle, exposure to glucocorticioids is characterized by a reduction in protein synthetic rate coincident with hampered translation initiation.

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2000-11, Vol.42 (5), p.E1185-E1190
Main Authors: SHAH, O. Jameel, ANTHONY, Joshua C, KIMBALL, Scot R, JEFFERSON, Leonard S
Format: Article
Language:English
Subjects:
Amino acids
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Hormones
Metabolism
Muscular system
Proteins
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
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Description
Summary:Glucocorticoids comprise an important class of hormaonal mediators of fuel and protein homeostasis in normal and pathological scenarios. In skeletal muscle, exposure to glucocorticioids is characterized by a reduction in protein synthetic rate coincident with hampered translation initiation.
ISSN:0193-1849
1522-1555