Insulin-mediated translocation of GLUT-4-containing vesicles is preserved in denervated muscles

Skeletal muscle denervation decreases insulin-sensitive glucose uptake into this tissue as a result of marked GLUT-4 protein downregulation (==20% of controls). The process of insulin-stimulated glucose transport in muscle requires the movement or translocation of intracellular GLUT-4-rich vesicles...

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2000-06, Vol.41 (6), p.E1019-E1026
Main Authors: MIN ZHOU, VALLEGA, G, KANDROR, K. V, PILCH, P. F
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Glucose
Insulin
Muscular system
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
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Summary:Skeletal muscle denervation decreases insulin-sensitive glucose uptake into this tissue as a result of marked GLUT-4 protein downregulation (==20% of controls). The process of insulin-stimulated glucose transport in muscle requires the movement or translocation of intracellular GLUT-4-rich vesicles to the cell surface, and it is accompanied by the translocation of several additional vesicular cargo proteins.
ISSN:0193-1849
1522-1555