Greater potency of IGF-I than IGF-I/BP-3 complex in catabolic parenterally fed rats

We compared the anabolic effects of recombinant human insulin-like growth factor I (rhIGF-I, 2.5 mg/kg) and equimolar amounts of rhIGF-I prebound to rhIGF binding protein-3 (rhIGF-I/BP-3) coinfused continuously with total parenteral nutrition (TPN) solution in dexamethasone (Dex, 70 jig/day ip)-trea...

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2000-02, Vol.41 (2), p.E252-E262
Main Authors: KRITSCH, K. R, HUSS, D. J, NEY, D. M
Format: Article
Language:English
Subjects:
Anatomy & physiology
Biological and medical sciences
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Nutrition
Rodents
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:We compared the anabolic effects of recombinant human insulin-like growth factor I (rhIGF-I, 2.5 mg/kg) and equimolar amounts of rhIGF-I prebound to rhIGF binding protein-3 (rhIGF-I/BP-3) coinfused continuously with total parenteral nutrition (TPN) solution in dexamethasone (Dex, 70 jig/day ip)-treated male rats for 6 days. The four TPN groups included control, Dex, Dex + IGF-I, and Dex+IGF-I/BP-3.
ISSN:0193-1849
1522-1555