Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells

A comprehensive metabolic study was carried out to understand how chronic exposure of pancreatic beta-cells to fatty acids causes high basal secretion and impairs glucose-induced insulin release.

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 1999-09, Vol.40 (3), p.E521-E528
Main Authors: SEGALL, L, LAMELOISE, N, ASSIMACOPOULOS-JEANNET, F, ROCHE, E, CORKEY, P, THUMELIN, S, CORKEY, B. E, PRENTKI, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cells
Diabetes
Endocrine pancreas
Fatty acids
Fundamental and applied biological sciences. Psychology
Hormones. Régulation
Insulin
Lipids
Metabolism
Obesity
Vertebrates: endocrinology
Online Access:Get full text
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Description
Summary:A comprehensive metabolic study was carried out to understand how chronic exposure of pancreatic beta-cells to fatty acids causes high basal secretion and impairs glucose-induced insulin release.
ISSN:0193-1849
1522-1555