Inverse alterations of BCKA dehydrogenase activity in cardiac and skeletal muscles of diabetic rats

A study of inverse alterations of branched-chain alpha-keto acid dehydrogenase (BCKAD) activity in cardiac and skeletal muscles of diabetic rats is presented. In diabetes the protein expression of BCKAD kinase is downregulated posttranscriptionally in the skeletal muscle, whereas it is upregulated p...

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 1999-10, Vol.40 (4), p.E685-E692
Main Authors: LOMBARDO, Y. B, SERDIKOFF, C, THAMOTHARAN, M, PAUL, H. S, ADIBI, S. A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diabetes
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrine system
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Heart
Medical sciences
Metabolism
Muscular system
Studies
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Summary:A study of inverse alterations of branched-chain alpha-keto acid dehydrogenase (BCKAD) activity in cardiac and skeletal muscles of diabetic rats is presented. In diabetes the protein expression of BCKAD kinase is downregulated posttranscriptionally in the skeletal muscle, whereas it is upregulated pretranslationally in the cardiac muscle, causing inverse alterations of BCKAD activity in these muscles.
ISSN:0193-1849
1522-1555