Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice

Because muscle triacylglycerol (TAG) accumulation might contribute to insulin resistance in leptin-deficient ob/ob mice, we studied the acute (60- to 90-min) effects of leptin and insulin on (14C) glucose and (14C) oleate metabolism in muscles isolated from lean and obese ob/ob mice.

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 1999-05, Vol.39 (5), p.E913-E921
Main Authors: MUOIO, D. M, DOHM, G. L, TAPSCOTT, E. B, COLEMAN, R. A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fatty acids
Insulin
Medical sciences
Metabolic diseases
Metabolism
Muscular system
Obesity
Rodents
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Description
Summary:Because muscle triacylglycerol (TAG) accumulation might contribute to insulin resistance in leptin-deficient ob/ob mice, we studied the acute (60- to 90-min) effects of leptin and insulin on (14C) glucose and (14C) oleate metabolism in muscles isolated from lean and obese ob/ob mice.
ISSN:0193-1849
1522-1555