3,5,3'-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity

To investigate the role of type II 5'-deiodinase (5'D-II) in the expression of mitochondrial uncoupling protein (UCP) in brown adipose tissue (BAT), we injected intact male rats with reverse (r) 3,5,3'-triiodothyronine (T3; 100 micro g-100 g body wt-1-day-1), an inhibitor of 5'D-...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 1999, Vol.39 (1), p.E179-E187
Main Authors: BRANCO, M, RIBEIRO, M, NEGRAO, N, BIANCO, A. C
Format: Article
Language:English
Subjects:
Biological and medical sciences
Body fat
Fundamental and applied biological sciences. Psychology
Heat
Hormones
Metabolism
Proteins
Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects
Thyroid gland
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate the role of type II 5'-deiodinase (5'D-II) in the expression of mitochondrial uncoupling protein (UCP) in brown adipose tissue (BAT), we injected intact male rats with reverse (r) 3,5,3'-triiodothyronine (T3; 100 micro g-100 g body wt-1-day-1), an inhibitor of 5'D-II, for 2-5 days.
ISSN:0193-1849
1522-1555