Ligand-specific regulation of proteasome-mediated proteolysis of estrogen receptor-α

Proteasome-mediated proteolysis modulates the cellular concentration of estrogen receptor-alpha (ERalpha) and is induced by treatment of cells with 17beta-estradiol. Herein, we show that multiple receptor agonists, including 17alpha-estradiol and estriol as well as the antagonist ICI-182780, stimula...

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2002-04, Vol.45 (4), p.E891-E898
Main Authors: PREISLER-MASHEK, Mara T, SOLODIN, Natalia, STARK, Bethany L, TYRIVER, Michael K, ALARID, Elaine T
Format: Article
Language:English
Subjects:
Biological and medical sciences
Clinical trials
Estrogens
Metabolism
Pituitary gland
Steroids
Online Access:Get full text
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Summary:Proteasome-mediated proteolysis modulates the cellular concentration of estrogen receptor-alpha (ERalpha) and is induced by treatment of cells with 17beta-estradiol. Herein, we show that multiple receptor agonists, including 17alpha-estradiol and estriol as well as the antagonist ICI-182780, stimulate proteasome-dependent proteolysis of ERalpha in a process that requires ligand binding to the receptor.
ISSN:0193-1849
1522-1555