Effects of cellular ATP depletion on glucose transport and insulin signaling in 3T3-L1 adipocytes

Glucosamine induced insulin resistancein 3T3-L1 adipocytes, which was associated with a 15% decrease in cellular ATP content. To study the role of ATP depletion in insulin resistance, we employed sodium azide (NaN3) and dinitrophenol (DNP), which affect mitochondrial oxidative phosphorylation, to ac...

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2001-03, Vol.43 (3), p.E428-E435
Main Authors: KANG, Jione, HEART, Emma, SUNG, Chin K
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cells
Endocrine pancreas
Fundamental and applied biological sciences. Psychology
Glucose
Hormones. Régulation
Insulin
Phosphates
Vertebrates: endocrinology
Online Access:Get full text
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Summary:Glucosamine induced insulin resistancein 3T3-L1 adipocytes, which was associated with a 15% decrease in cellular ATP content. To study the role of ATP depletion in insulin resistance, we employed sodium azide (NaN3) and dinitrophenol (DNP), which affect mitochondrial oxidative phosphorylation, to achieve a similar 15% ATP depletion.
ISSN:0193-1849
1522-1555