MRI correlates of chronic symptoms in mild traumatic brain injury

Veterans with mild traumatic brain injury (mTBI) have reported auditory and visual dysfunction that persists beyond the acute incident. The etiology behind these symptoms is difficult to characterize with current clinical imaging. These functional deficits may be caused by shear injury or micro-blee...

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Bibliographic Details
Published in:arXiv.org 2020-06
Main Authors: Kerley, Cailey I, Schilling, Kurt G, Blaber, Justin, Miller, Beth, Newton, Allen, Anderson, Adam W, Landman, Bennett A, Rex, Tonia S
Format: Article
Language:English
Subjects:
Bleeding
Brain
Etiology
Head injuries
Magnetic resonance imaging
Medical imaging
Traumatic brain injury
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Summary:Veterans with mild traumatic brain injury (mTBI) have reported auditory and visual dysfunction that persists beyond the acute incident. The etiology behind these symptoms is difficult to characterize with current clinical imaging. These functional deficits may be caused by shear injury or micro-bleeds, which can be detected with special imaging modalities. We explore these hypotheses in a pilot study of multi-parametric MRI. We extract over 1,000 imaging and clinical metrics and project them to a low-dimensional space, where we can discriminate between healthy controls and patients with mTBI. We also show correlations between the metric representations and patient symptoms.
ISSN:2331-8422