Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein

Type C Niemann-Pick disease is due to a mutation in Niemann-Pick C (NPC) protein, a putative determinant of intracellular cholesterol transport. This study quantifies cholesterol balance in vivo across all tissues in mice with this defect.

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 1999-02, Vol.39 (2), p.E336-E344
Main Authors: CHONGLUN XIE, TURLEY, S. D, PENTCHEV, P. G, DIETSCHY, J. M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cholesterol
Disease
Errors of metabolism
Lipids (lysosomal enzyme disorders, storage diseases)
Medical sciences
Metabolic diseases
Metabolism
Mutation
Proteins
Rodents
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Description
Summary:Type C Niemann-Pick disease is due to a mutation in Niemann-Pick C (NPC) protein, a putative determinant of intracellular cholesterol transport. This study quantifies cholesterol balance in vivo across all tissues in mice with this defect.
ISSN:0193-1849
1522-1555