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Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein

Type C Niemann-Pick disease is due to a mutation in Niemann-Pick C (NPC) protein, a putative determinant of intracellular cholesterol transport. This study quantifies cholesterol balance in vivo across all tissues in mice with this defect.

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Published in:	American journal of physiology: endocrinology and metabolism 1999-02, Vol.39 (2), p.E336-E344
Main Authors:	CHONGLUN XIE, TURLEY, S. D, PENTCHEV, P. G, DIETSCHY, J. M
Format:	Article
Language:	English
Subjects:	Biological and medical sciences Cholesterol Disease Errors of metabolism Lipids (lysosomal enzyme disorders, storage diseases) Medical sciences Metabolic diseases Metabolism Mutation Proteins Rodents
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creator	CHONGLUN XIE TURLEY, S. D PENTCHEV, P. G DIETSCHY, J. M
description	Type C Niemann-Pick disease is due to a mutation in Niemann-Pick C (NPC) protein, a putative determinant of intracellular cholesterol transport. This study quantifies cholesterol balance in vivo across all tissues in mice with this defect.
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source	American Physiological Society Free
subjects	Biological and medical sciences Cholesterol Disease Errors of metabolism Lipids (lysosomal enzyme disorders, storage diseases) Medical sciences Metabolic diseases Metabolism Mutation Proteins Rodents
title	Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein
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