Nasal instillation of probiotic extracts inhibits experimental allergic rhinitis

 Allergic rhinitis (AR) is a common disease. The therapeutic efficacy of AR needs to be improved. This study aims to evaluate the effects of local administration of probiotic extracts on inhibiting experimental AR. Epithelial cells (ECs) were primed by exposing to extracts (CBe) in the culture to up...

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Bibliographic Details
Published in:Immunotherapy 2019-10, Vol.11 (15), p.1315-1323
Main Authors: Zeng, Xian-Hai, Yang, Gui, Liu, Jiang-Qi, Geng, Xiao-Rui, Cheng, Bao-Hui, Liu, Zhi-Qiang, Yang, Ping-Chang
Format: Article
Language:English
Subjects:
Allergic rhinitis
Antigens
Asthma
B cells
CD4 antigen
Cell culture
Cell proliferation
Cytokines
Dermatitis
Epithelial cells
Experiments
Food allergies
immune regulation
Immunoglobulins
Immunotherapy
Interleukin 10
Lymphocytes
Lymphocytes B
Lymphocytes T
nasal mucosa
Nose
Probiotics
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Summary: Allergic rhinitis (AR) is a common disease. The therapeutic efficacy of AR needs to be improved. This study aims to evaluate the effects of local administration of probiotic extracts on inhibiting experimental AR. Epithelial cells (ECs) were primed by exposing to extracts (CBe) in the culture to upregulate the expression of IL-10. A mouse AR model was developed to assess the therapeutic potential of CBe in AR. CBe markedly induced the expression of IL-10 in ECs. Co-culture of naive B cells with CBe-primed ECs significantly increased IL-10 expression in the B cells (iB10 cells). The iB10 cells showed immune suppressive function in suppressing effector CD4 T-cell proliferation. Treatment with nasal drops containing CBe efficiently inhibited experimental AR in mice. Local administration of CBe can efficiently inhibit experimental AR.
ISSN:1750-743X
1750-7448
DOI:10.2217/imt-2019-0119