Tlr7 Agonist in Combination With Salmonella as an Effective Antimelanoma Immunotherapy

Aim: We evaluated a novel approach combining the use of attenuated Salmonella immunotherapy with a Toll-like receptor agonist, imiquimod, in B16F1 melanoma-bearing mice. Materials & methods: B16F1 melanoma-bearing mice were daily treated with topical imiquimod in combination with one intratumora...

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Bibliographic Details
Published in:Immunotherapy 2018-06, Vol.10 (8), p.665-679
Main Authors: Vola, Magdalena, Mónaco, Amy, Bascuas, Thais, Rimsky, Geraldine, Agorio, Caroline Isabel, Chabalgoity, José Alejandro, Moreno, María
Format: Article
Language:English
Subjects:
Agonists
Animals
Antitumor activity
Antiviral drugs
Bacteria
Cell culture
Chemokines
Cytokines
Cytotoxicity
Granulocytes
Imiquimod
Immunotherapy
Inflammation
Lymphocytes T
Melanoma
Metastases
Metastasis
Neutrophils
Salmonella
Skin cancer
TLR7 protein
Toll-like receptors
Tumors
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Summary:Aim: We evaluated a novel approach combining the use of attenuated Salmonella immunotherapy with a Toll-like receptor agonist, imiquimod, in B16F1 melanoma-bearing mice. Materials & methods: B16F1 melanoma-bearing mice were daily treated with topical imiquimod in combination with one intratumoral injection of attenuated Salmonella enterica serovar Typhimurium LVR01. Results: The combined therapy resulted in retarded tumor growth and prolonged survival. Combination treatment led to an enhancement in the expression of pro-inflammatory cytokines and chemokines in the tumor microenvironment, with a Th1-skewed profile, resulting in a broad antitumor response. The induced immunity was effective in controlling the occurrence of metastasis. Conclusion:Salmonella LVR01 immunotherapy in combination with imiquimod is a novel approach that could be considered as an effective antimelanoma therapy.
ISSN:1750-743X
1750-7448
DOI:10.2217/imt-2017-0188