Interleukin-1[alpha] and -1[beta] Promoter Polymorphisms in Taiwanese Patients with Dementia

• Published in: Dementia and geriatric cognitive disorders 2007-07, Vol.24 (2), p.104
• Main Authors: Wang, Hsiu-Kuan, Hsu, Wen-Chuin, Hon-Chung, Fung, Jun-Cheng, Lin, Hai-Pei Hsu, Wu, Yih-Ru, Hsu, Yuying, Fen-Ju Hu, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
• Format: Article
• Language: English
• Subjects: Dementia
• ISSN: 1420-8008; 1421-9824

Background: Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. We investigated whether IL-1[alpha] -889 C/T and IL-1[beta] -511 C/T promoter polymorphisms are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD). Methods: AD patients (n = 219) and VaD patients (n = 82), who fulfilled the criteria of the NINCDS-ADRDA and NINDS-AIREN, and ethnic-matched and nondemented controls (n = 209) were analyzed by means of genotype association method. Results: No significant difference in the genotype distribution of the analyzed single nucleotide polymorphisms was found between AD or VaD cases and controls. However, the frequency of the IL-1[alpha] -889 CT genotype was notably lower in VaD patients aged over 70 years than the age-matched controls (9.1 vs. 22.9%, p = 0.036) andtheIL-1[alpha] -889 CT genotype demonstrated a trend toward decrease in risk of developing VaD (odds ratio: 0.34; 95% confidence interval: 0.12-0.83, p = 0.026). Multivariate analysis revealed that the IL-1[beta] -511T-carrying genotype slightly strengthens the negative association of the IL-1[alpha] -889 CT genotype with VaD (odds ratio: 0.26; 95% confidence interval: 0.08-0.79, p = 0.024). Conclusion: Our data suggest a protective role of the IL-1[alpha] -889 CT genotype in VaD susceptibility among Taiwanese aged over 70 years. Copyright © 2007 S. Karger AG, Basel