Differences in Risk Factors for Dementia with Neurodegenerative Traits and for Vascular Dementia

In 229 patients with dementia and in 144 control subjects, polymorphisms of apolipoprotein E (ApoE), low-density-lipoprotein (LDL)-receptor-related protein, α 2 -macroglobulin, interleukin (IL) 1β, angiotensin-converting enzyme and of methylene tetrahydrofolate reductase genes were investigated. In...

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Published in:Dementia and geriatric cognitive disorders 2006-01, Vol.22 (1), p.1-7
Main Authors: Wehr, H., Bednarska-Makaruk, M., Łojkowska, W., Graban, A., Hoffman-Zacharska, D., Kuczyńska-Zardzewiały, A., Mrugała, J., Rodo, M., Bochyńska, A., Sułek, A., Ryglewicz, D.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antibodies, Bacterial - analysis
Apolipoprotein E4
Apolipoproteins E - genetics
Biological and medical sciences
Cardiology. Vascular system
Chlamydia Infections - epidemiology
Chlamydia Infections - immunology
Chlamydophila pneumoniae - immunology
Cholesterol - blood
Coronary heart disease
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Dementia - epidemiology
Dementia - genetics
Dementia, Vascular - epidemiology
Dementia, Vascular - genetics
Environment
Female
Gene Frequency
Genotype
Heart
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Lipids - blood
Male
Medical sciences
Middle Aged
Neurodegenerative Diseases - epidemiology
Neurodegenerative Diseases - genetics
Neurology
Original Research Article
Polymorphism, Genetic - genetics
Psychiatric Status Rating Scales
Risk Factors
Triglycerides - blood
Vascular diseases and vascular malformations of the nervous system
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Summary:In 229 patients with dementia and in 144 control subjects, polymorphisms of apolipoprotein E (ApoE), low-density-lipoprotein (LDL)-receptor-related protein, α 2 -macroglobulin, interleukin (IL) 1β, angiotensin-converting enzyme and of methylene tetrahydrofolate reductase genes were investigated. In plasma, antibodies against Chlamydia pneumoniae and lipids were determined. Dementia was classified as probable Alzheimer’s disease (AD), probable dementia of vascular origin (VaD) and mixed dementia (MD). An association of the disease with ApoE and IL-1β polymorphism and increased levels of LDL cholesterol were observed in AD and in MD but not in VaD.
ISSN:1420-8008
1421-9824
DOI:10.1159/000092845