Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A

Toxin A (TxA) of Clostridium difficile induces acute inflammation of the intestine initiated by release of substance P (SP) and activation of the neurokinin-1 receptor. However, the mechanisms that terminate this response are unknown.

Saved in:
Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 2001-08, Vol.44 (2), p.G544-G551
Main Authors: KIRKWOOD, Kimberly S, BUNNETT, Nigel W, MAA, John, CASTAGLIOLO, Ignazio, BAO LIU, GERARD, Norma, ZACKS, Jeff, POTHOULAKIS, Charalabos, GRADY, Eileen F
Format: Article
Language:English
Subjects:
Bacterial diseases
Biological and medical sciences
Bowel disease
Enzymes
Experimental bacterial diseases and models
Infectious diseases
Medical sciences
Peptides
Poisons
Stomach
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Toxin A (TxA) of Clostridium difficile induces acute inflammation of the intestine initiated by release of substance P (SP) and activation of the neurokinin-1 receptor. However, the mechanisms that terminate this response are unknown.
ISSN:0193-1857
1522-1547